Evidence-based clinical guidance, treatment protocols, and research updates for healthcare workers
A Phase I dose-escalation safety trial of a human monoclonal antibody targeting the Sin Nombre virus Gn glycoprotein. The antibody demonstrated complete protection in Syrian hamster and cynomolgus macaque models. This first-in-human trial evaluates s...
A Phase II, randomised, double-blind, placebo-controlled trial evaluating the immunogenicity, safety, and preliminary efficacy of HantaVax-SN, a DNA-plasmid vaccine encoding the Sin Nombre virus nucleocapsid protein and glycoproteins. Three intramusc...
A multicentre, randomised pilot trial evaluating the safety and efficacy of high-titre anti-Sin Nombre virus convalescent plasma in patients with confirmed severe HPS (requiring ICU admission). Plasma is collected from recovered HPS patients with neu...
An open-label, randomised controlled trial evaluating favipiravir (T-705), a broad-spectrum RNA polymerase inhibitor, in patients with confirmed Puumala virus Hemorrhagic Fever with Renal Syndrome presenting within 5 days of fever onset. Conducted in...
A prospective observational study with historical controls comparing outcomes of veno-venous ECMO versus maximal conventional mechanical ventilation in patients with severe HPS (PaO2/FiO2 <100 or pH <7.2). Conducted across 8 ECMO-capable centres in t...
A randomised, double-blind, placebo-controlled trial evaluating the efficacy and safety of intravenous ribavirin administered within 7 days of symptom onset in patients with confirmed Hantavirus Pulmonary Syndrome. Primary endpoint is 28-day all-caus...
| Outcome | Cases | Avg. LOS | Avg. Age | Ventilator Use | ICU Admission |
|---|---|---|---|---|---|
| Recovered | 3 | 0 days | 0 years | 0 cases | 0 cases |
| Died | 1 | 0 days | 0 years | 0 cases | 0 cases |
| Active | 6 | 0 days | 0 years | 0 cases | 0 cases |
Authors: Glass GE, Cheek JE, Patz JA, Tong T, Kelen GD, Schwartz BS
Analysis of 30-year HPS surveillance data correlated with climate indices reveals El Niño Southern Oscillation (ENSO) events precede HPS case surges ...
Authors: Lemos ER, Jonsson CB, Jonsson LM, Jandolo B
5-year longitudinal follow-up of 67 HPS survivors from index admission. At 5 years: 18% had persistent exercise intolerance (6MWT distance >20% below ...
Authors: Mackow ER, Gavrilovskaya IN, Bharadwaj M, Bhatt DL
This systematic review of 847 confirmed HPS cases across 14 studies describes the clinical spectrum, pathophysiological mechanisms, and current treatm...
Authors: Manigold T, Vial P, Ferres M, Hjelle B
Systematic meta-analysis of hantavirus seroprevalence studies across 52 countries, comprising data from 218 studies and 287,000 participants. Global s...